新的研究网络：希望能发现反对结肠癌的人！
新的研究网络：希望能发现反对结肠癌的人！
Frankfurt am Main, Deutschland - On May 30, 2025, the new Transregio special research area TRR 417 was launched, which is operated together by the Goethe University in Frankfurt, the Friedrich Alexander University Erlangen-Nuremberg and the Albert-Ludwigs University Freiburg. The aim of research is to examine the tumor micromilia of intestinal tumors more precisely and to improve the therapy options through targeted changes. According to puk.uni-frankfurt.de , colon cancer is curable if it is recognized at an early stage and fully operated 在。在晚期病例中，免疫疗法被认为是有希望的，但只有约15-20％的患者对这些治疗进行了交谈。
新研究的一个主要方面是具有微卫星不稳定性的肿瘤的DNA修复系统缺陷。 This opens up better opportunities for the use of immunotherapies, since immuncheck point inhibitors can neutralize the protective cover of the tumor and activate T cells. Prof. Florian Greten, spokesman for TRR 417, emphasizes the need for interdisciplinary cooperation in order to transfer basic research into clinical applications faster.
治疗微卫星稳定肿瘤的新方法
A significant challenge in the treatment of colon cancer is the microsatellite-stable colorectal carcinoma (MSS CRC), which is about 85-90% of cases.当前，现代免疫疗法只能在这种类型的肿瘤中在有限的程度上使用。维也纳Meduni的研究团队已经确定了这些疗法失败的可能原因。 In a recently published study in "Nature Communications", the scientists found that the Yẟ T cells who are responsible for the immune response do not work sufficiently in MSS CRC.除其他外，这是由于结缔组织细胞（成纤维细胞）阻止了这些T细胞的活性。 Krebs-nachrichten.de describes further promising approaches to overcoming this blockade, in particular by inhibiting the分子tigit。
The knowledge about the role of the Yẟ T cells open up new perspectives for future research that should examine their interactions with fibroblasts more precisely.这可能是对抗结肠癌的斗争的决定性进展，到目前为止，接受免疫疗法的接受程度有限。
微生物组对免疫疗法的影响
In the meantime, the Tübingen Professor Dr. Christoph Stein-Thoeringer for his project, which examines the influence of intestinal microbes on the effectiveness of car-t cell therapies, an ERC consolidator grant over two million euros. Car-T cell therapies offer new immune treatment in which T cells are changed in genetic engineering in order to combat tumor cells in a targeted manner.尽管淋巴瘤的结果有望，但研究人员认为有必要改善。治疗后，大约60％的患者会经历该疾病的复发。 Stein-Thoeringer的研究重点是鉴定可以预测治疗反应的生物标志物。 Notes indicate that specific intestinal bacteria could influence the prediction of therapy success, which indicates an important role in microbioma in cancer immunotherapy, as uni-tuebingen.de reported.总的来说，当前的研究表明，对生物学机制的理解与结肠癌及其疗法相比。基础研究中的创新方法最终可以在治疗这种严重疾病的治疗方面带来决定性的突破。
| Details | |
|---|---|
| Ort | Frankfurt am Main, Deutschland |
| Quellen | |