New approach in Kiel: Nutrition could help CED patients!

New approach in Kiel: Nutrition could help CED patients!

chronic inflammatory bowel diseases (CED) such as Crohn's disease and ulcerative colitis are a significant challenge in modern medicine. These diseases lead to symptoms such as diarrhea, fever, pain and psychological stress. A current study by a research team from the Christian Albrechts University in Kiel (CAU) and the University Hospital Schleswig-Holstein (UKSH) has identified a decisive factor: the disturbed metabolism between the body and the patient's microbioma. The results were published in the Nature Communications specialist magazine, whereby it was found that only a part of the patients responded to conventional drug therapies.

according to the Reporting of Precision Medicine examined. There was a dramatically reduced metabolic activity in the intestinal tissue and in the microbioma of the patients, which led to a breakdown of the metabolic interactions between host and microbioma. The reduction of important metabolic products such as tryptophan and choline in the blood, which are important for the production of NAD and ATP, was particularly striking.

The role of the microbiome

The intestinal microbioma, the largest microbiome in humans, plays a crucial role in the health of the intestine. According to Journalmed , the composition of the intestinal microbiota, which consists of a variety of microbes, influences general health. Dysbiosis, an imbalance in the microbiota, can lead to increased inflammation and other serious health problems. A healthy diet can promote useful bacteria that maintain the integrity of the intestinal barrier and support the immune system.

The study from Kiel has also shown that individual nutrition is gaining in importance. Computer models indicate that targeted nutritional adjustments could have a positive impact on the microbiome and brakes inflammatory processes. However, no universal diet was identified for all patients; Rather, the nutrition must be individually adjusted to achieve optimal results.

therapeutic developments and outlook

The current treatment of CED mainly aims at the immune system, which is not always successful. The Information from my life with ced show that CED is not curable, but there are effective treatment options to improve the quality of life. In Switzerland, an estimated 25,000 people live with a CED, with the most common forms of Crohn and Colitis Ulcerosa.

The next phase of research aims at laboratory examinations to develop specific therapies. The focus is currently on the combination of metagenomics, transcriptomics, metabolomics and network analyzes in order to create a better understanding of the metabolic changes in CED patients. Access to individual nutritional strategies could be a promising approach to influence the disease in the long term and to improve the quality of life of those affected.